Description

TMPRSS2:ERG is the most prevalent gene rearrangement in prostate cancers leading to overexpression of a truncated ERG protein in a subset of prostate cancers. ERG expression is also reported in high-grade prostatic intraepithelial neoplasia (PIN). Publications suggest that the prevalence of the TMPRSS2:ERG rearrangement in prostate cancer cases ranges from ~25% to 70%. ERG is expressed in many tissues including vascular tumors.